0526 GMT September 18, 2019
The material helps healthy cells 'win the race' to the medical implant, beating off competition from bacterial cells and thus reducing the likelihood of the implant being rejected by the body, sciencenewsline.com said.
The failure rate of certain medical implants still remains high, around 40 percent for hip implants, due to the formation of biofilms when the implant is first inserted into the body.
This thin film is composed of a group of microorganisms stuck together and can be initiated by bacteria sticking to the implant. This prevents healthy cells from attaching and results in the body eventually rejecting the implant, potentially leading to serious complications for patients.
In their study, researchers from A*STAR (Agency for Science, Technology and Research) in Singapore, Nanyang Technological University and City University of Hong Kong produced a material that not only repelled bacteria but also attracted healthy cells.
The base of the material was made from polyelectrolyte multilayers onto which a number of specific bonding molecules, called ligands, were attached.
After testing various concentrations of different ligands, the researchers found that RGD peptide was particularly effective at inhibiting the attachment of bacterial cells and attracting healthy cells, compared with collagen, when attached to dextran sulfate and chitosan multilayers.
This combination was tested on cultures of healthy fibroblast cells and cultures of bacterial cells, in which two specific strains were used, E. coli and S. aureus.