0728 GMT April 08, 2020
The world-first procedure at Necker Children's Hospital in Paris offers hope to millions of people with the blood disorder, according to BBC.
Scientists altered the genetic instructions in his bone marrow so it made healthy red blood cells.
So far, the therapy has worked for 15 months and the child is no longer on any medication.
Sickle cell disease causes normally round red blood cells, which carry oxygen around the body, to become shaped like a sickle.
These deformed cells can lock together to block the flow of blood around the body. This can cause intense pain, organ damage and can be fatal.
The teenager who received the treatment had so much internal damage he needed to have his spleen removed and his hips replaced.
Every month he had to go into hospital to have a blood transfusion to dilute his defective blood.
But when he was 13, doctors at the Necker Children's Hospital in Paris did something unique.
No sign of disease
Doctors removed his bone marrow — the part of the body that makes blood. They then genetically altered it in a lab to compensate for the defect in his DNA that caused the disease.
Sickle cell is caused by a typo in the instructions for making the protein hemoglobin, which is densely packed into red blood cells.
A virus was used to infect the bone marrow with new, correct instructions.
The corrected bone marrow was then put back into the patient.
The results in the New England Journal of Medicine showed the teenager has been making normal blood since the procedure 15 months ago.
Philippe Leboulch, a professor of medicine at the University of Paris, said: "So far the patient has no sign of the disease, no pain, no hospitalization. He no longer requires a transfusion so we are quite pleased with that.
"But of course we need to perform the same therapy in many patients to feel confident that it is robust enough to propose it as a mainstream therapy."
Leboulch is nervous about using the word 'cure' as this is just the first patient to come through clinical trials.
But the study does show the potential power of gene therapy to transform the lives of people with sickle cell.
Dr. Deborah Gill from the gene medicine research group at the University of Oxford, said, "I think it's very significant, essential they've given him his life back.
"I've worked in gene therapy for a long time and we make small steps and know there's years more work.
"But here you have someone who has received gene therapy and has complete clinical remission — that's a huge step forward."
However, the expensive procedure can only be carried out in cutting-edge hospitals and laboratories, while most sickle cell patients are in Africa.
The next big challenge will be to transform this pioneering science into something that really can help millions of people.