1015 GMT January 25, 2020
Nearly two-fifths of sufferers went on to make a full recovery when they were given the mechanical pump, express.co.uk reported.
A national shortage of donated hearts for transplant is leading to calls for the battery-operated machines to be considered as a tool which can allow patients to fully restore their health.
The pumps are currently used to support patients with severe heart failure while they wait for a transplant.
A spokesman for the team at Newcastle University Dr. Djordje Jakovljevic said: “For the first time, what we have shown is that heart function is restored in some patients to the extent that they are just like someone healthy who has never had heart disease.
“We talk about these devices as a bridge-to-transplant, something which can keep a patient alive until a heart is available for transplantation.”
But the ground-breaking research showed how some patients were able to recover to such an extent that they no longer need the transplant.
Jakovljevic added, “In effect, these devices can be a bridge to full recovery in some patients.”
The researchers examined the effect of mechanical heart pumps, known as left ventricular assist devices (LVADs).
Surgeons implant the machine, which helps the main pumping chamber of the heart — the left ventricle — to push blood around the body.
Fitted at the six specialist NHS centers across Britain, LVADs are used for patients who have reached the end stage of heart failure.
Publishing in the Journal Of American College Of Cardiology, the team explained the clinical trial, in which 58 men with heart failure were tested for heart fitness levels.
Of those, 16 were fitted with an LVAD and then had it removed due to their recovery. Eighteen still had an LVAD and 24 patients were waiting for a heart transplant.
On average, a patient had a device fitted for 396 days before it was removed. The participants were compared with 97 healthy men who had no known heart disease.
The authors said 38 percent of people who recovered enough to allow the device to be removed demonstrated a heart function equivalent to that of a healthy individual of the same age.
Jakovljevic said: “We can consider these pumps as a tool which can lead to a patient recovering, rather than as a device which keeps people alive until a heart transplant is available.”
Now the team is researching markers that will indicate if and when to remove the pumps while ensuring heart failure will not occur again.
The average price of a LVAD is around £80,000 and the transplant operation costs £69,000.
Dr. Guy MacGowan, consultant cardiologist within the Newcastle upon Tyne Hospitals NHS Foundation Trust, and Honorary Clinical Reader in Heart Failure at Newcastle University, is coauthor of the paper.
He said: “It is very difficult to get a heart transplant, especially in the UK, so any alternative treatment is important and recovery of heart function especially so.”
Cardiovascular (heart and circulatory) disease causes 26 percent of all deaths in the UK, with nearly 160,000 deaths each year.
Professor Jeremy Pearson, associate medical director at the British Heart Foundation, said: “This research is extremely encouraging and shows there may, finally, be hope for people who are living with advanced heart failure.
"But it’s vital we continue funding research into repairing damaged hearts.”