The Britain-based Syrian Observatory for Human Rights said the aerial attack hit the village of Al-Dablan, located about 20 kilometers (13 miles) southeast of Mayadin town, early on Wednesday, according to Press TV.
The deadly airstrike is the second in 48 hours that the US-led coalition has conducted in Dayr al-Zawr Province.
On Monday, dozens of people lost their lives when a string of coalition strikes targeted a jail run by Daesh terrorists in Mayadin, located some 45 kilometers (28 miles) southeast of the provincial capital of Dayr al-Zawr.
The observatory said the aerial assaults left 42 prisoners and 15 Daesh terrorists dead.
The US-led coalition has been conducting airstrikes against what are said to be Daesh targets inside Syria since September 2014 without any authorization from the Damascus government or a UN mandate.
The military alliance has repeatedly been accused of targeting and killing civilians. It has also been largely incapable of fulfilling its declared aim of destroying Daesh.
Syria has been fighting different foreign-sponsored terrorist groups since March 2011. UN Special Envoy for Syria Staffan de Mistura estimated last August that more than 400,000 people had been killed in the crisis until then.