The accident occurred on Tuesday around 10 km outside the town of Bambari, around 300 km northeast of the capital Bangui, as the truck was travelling to a weekly market day in the village of Maloum, according to hindustantimes.com.
“At the moment, we have counted 78 dead and 72 wounded. Some wounded were taken directly to their homes from the accident scene and died there some time after, but most died here,” said Chamberlain Bama, chief doctor at the university hospital in Bambari.
A member of parliament from Bambari said the truck was overloaded and travelling faster than normal.
“They were driving fast to make it to the market on time. That’s what probably caused the accident,” Amaseka Topi told Reuters.
Decades of neglect have left the landlocked country’s road system in ruins and safety regulations are rarely enforced.
Central African Republic is racked by violence unleashed after mainly Muslim rebels ousted President Francois Bozize in 2013, provoking a backlash from Christian militias.
Thousands have died and a fifth of Central Africans have fled their homes.