News ID: 208174
Published: 0558 GMT January 16, 2018

Genes that aid spinal cord healing in lamprey also present in humans

Genes that aid spinal cord healing in lamprey also present in humans
Jennifer Morgan and Ona Bloom with juvenile lamprey in the MBL Whitman Center.
science daily

Many of the genes involved in natural repair of the injured spinal cord of the lamprey are also active in the repair of the peripheral nervous system in mammals, according to a study by a collaborative group of scientists at the Marine Biological Laboratory (MBL) and other institutions.

This is consistent with the possibility that in the long term, the same or similar genes may be harnessed to improve spinal cord injury treatments, .science daily wrote.

Jennifer Morgan, director of the MBL's Eugene Bell Center for Regenerative Biology and Tissue Engineering, one of the authors of the study published in Scientific Reports, said, "We found a large overlap with the hub of transcription factors that are driving regeneration in the mammalian peripheral nervous system.”

Lampreys are jawless, eel-like fish that shared a common ancestor with humans about 550 million years ago.

This study arose from the observation that a lamprey can fully recover from a severed spinal cord without medication or other treatment.

Morgan said, "They can go from paralysis to full swimming behaviors in 10 to 12 weeks.

Ona Bloom of the Feinstein Institute for Medical Research and the Zucker School of Medicine at Hofstra-Northwell, a former MBL Whitman Center Fellow who collaborated on the project, said, "Scientists have known for many years that the lamprey achieves spontaneous recovery from spinal cord injury, but we have not known the molecular recipe that accompanies and supports this remarkable capacity.

"In this study, we have determined all the genes that change during the time course of recovery and now that we have that information, we can use it to test if specific pathways are actually essential to the process.”

The researchers followed the lampreys' healing process and took samples from the brains and spinal cords at multiple points in time, from the first hours after injury until three months later when they were healed.

They analyzed the material to determine which genes and signaling pathways were activated as compared to a non-injured lamprey.

As expected, they found many genes in the spinal cord that change over time with recovery. Somewhat unexpectedly, they also discovered a number of injury-induced gene expression changes in the brain.

Morgan said, "This reinforces the idea that the brain changes a lot after a spinal cord injury.

"Most people are thinking, 'What can you do to treat the spinal cord itself?' but our data really support the idea that there's also a lot going on in the brain."

They also found that many of the genes associated with spinal cord healing are part of the Wnt signaling pathway, which plays a role in tissue development.

He said, "Furthermore, when we treated the animals with a drug that inhibits the Wnt signaling pathway, the animals never recovered their ability to swim.”

Future research will explore why the Wnt pathway seems particularly important in the healing process.

The paper is the result of a collaboration between Morgan, Bloom and other scientists including Jeramiah Smith of University of Kentucky and Joseph Buxbaum of Icahn School of Medicine at Mount Sinai, both former Whitman Center Fellows.

The collaboration was made possible by the MBL Whitman Center Fellowship program.

Morgan said, "[This study] involved several different labs located in different parts of the country with different types of expertise, but it absolutely could not and would not have been done without the support of the MBL that allows us to work collaboratively in a shared laboratory setting.”

 

   
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