The Iranian side has won both of its home games and secured its place in the next round following a scoreless draw away at Nasaf two weeks ago, the-afc.com reported.
Al Sadd currently occupies first position and two more goals from striker Baghdad Bounedjah in a 2-1 victory over Al Wasl in early April confirmed a place in the last 16.
The host, which is without the suspended Shoja Khalilzadeh, drew 1-1 with Pars Jam Bushehr on Wednesday although the Reds have already been crowned Iranian champions.
The visitor’s last Qatar Stars League game was a 9-1 victory over Al Kharitiyath just over a week ago as it brought a poor recent domestic run to an end.
Elsewhere, bottom faces top in Group D of competitions when Al Hilal takes on Esteghlal at Kuwait Sports Club Stadium.
Esteghlal is already assured of a place in the next round having beaten Al Rayyan 2-0 in early April, but the Iranian side must avoid defeat to win the group.
The two-time continental champion, which is without suspended duo Roozbeh Cheshmi and Omid Ebrahimi, warmed up for the game with a 1-1 draw against Gostaresh Foolad Tabriz last week.
Runner-up last year, Al Hilal’s form has dropped dramatically this time round and its 2-1 defeat in Al Ain on Matchday Five confirmed the Saudi side’s early elimination.
The Saudi giant goes into the game on a high, though, after a 4-1 win over Al Fateh secured the Saudi Pro League title on Thursday. Ali Al Bulayhi misses the game through suspension.