Sanders and principal Deputy Press Secretary Raj Shah are both heading for the exits, CBS News reported on Wednesday, citing sources in the Trump administration, according to presstv.ir.
Sanders, who is considered a confidante of President Trump, has reportedly told friends about her plans to quit her job at the White House.
Sanders did not deny the report in a tweet sent about an hour after the report was published.
Shah is also considering his exit, but has not yet decided on a departure date.
Sanders and Shah are among the most visible members of the Trump administration.
Sanders previously worked in the White House as deputy press secretary under then-press secretary Sean Spicer. She became the main White House spokesperson after Spicer resigned in July last year.
Shah worked for the Republican National Committee (RNC) during the 2016 campaign season, and later joined the Trump White House.