0453 GMT January 19, 2020
The club has yet to sign a direct replacement for the Portuguese superstar, who switched to Juventus in July after scoring 450 goals in 438 games over nine seasons at the club, AFP reported.
"Instead of asking who will score those goals we need to challenge ourselves by scoring more than that as a team," Lopetegui said.
"The whole team will have to score all those goals (that Ronaldo scored) between them. Score more goals and concede less of them."
Madrid boasts Welsh winger Gareth Bale, French striker Karim Benzema and rising 22-year-old Marco Asensio in its forward line but has just five days of the current Spanish transfer window left if it is to buy a new striker.
Some reports have said Real is waiting to see if it can lure World Cup sensation Kylian Mbappe away from Paris Saint-Germain.
"It would be useless to put that terrible pressure (of replacing Ronaldo) on one person, it would be a sword of Damocles," Lopetegui said.
"We have a wonderful squad and I'm delighted with all of them because I can see they are ready to give everything to win the league and all the other competitions," he said.