James had 28 points and seven assists and the Lakers defeated the Trail Blazers 114-110 Saturday night, The Associated Press reported.
The Lakers snapped the franchise's 16-game losing streak against the Blazers. In addition to the streak, Saturday was the Lakers' first road win this season against a team with a winning record.
"Great to snap that," James said of the Lakers' streak of futility against Portland. "They're a very good team, obviously. To beat Portland, you can't just come in and win without playing really hard and really well."
Rajon Rondo gave the Lakers a huge lift off the bench, finishing with 17 points and 10 assists in 25 minutes.
Damian Lillard and CJ McCollum each scored 30 points for Portland.
"LeBron closed them out over the final three minutes," Lakers head coach Luke Walton said of James.
JaVale McGee, who James said is a candidate for Defensive Player of the Year, also had six blocks to add to his league-leading total.
"He's doing a little bit of everything," James said of McGee. "He's leading the league in blocks. And tonight he saved us and covered our defensive mistakes with blocks at the rim."
Portland shot a six-for-35 (17 percent) from beyond the arc and shot just 42 percent from the field overall.
"Our defense won us the game tonight," Walton said. "They missed some 3s, but we were contesting, chasing over the top and defending."
"Our second unit was outstanding tonight," Walton said.
"Rondo led it and then the lift that (Ivica) Zubac gave us off the bench was incredible."
James Harden scored 25 points, dished seven assists and added four steals as the visiting Houston Rockets pulled away for a 96-88 win over the Chicago Bulls on Saturday night.
Carmelo Anthony (17 points) and James Ennis III (15 points) were among three other Rockets to finish in double figures, Reuters reported.
Houston earned its second win in a row after losing the previous four.
Zach LaVine led the Bulls with 21 points during an unusual night in which he shot four of 16 from the field and 12 of 13 from the free-throw line. Jabari Parker added 15 points on six-for-12 shooting for the Bulls, who have dropped four in a row.
Harden, playing in his first game after missing three straight because of a strained left hamstring, scored 11 points unanswered during the third quarter.
He hit back-to-back three-pointers, sank a pair of free throws and made another three-pointer to increase Houston’s lead from 60-59 to 71-59.