The Serbian world number one and his Swiss opponent have won eight of the nine titles on Rod Laver Arena since 2010 and 11 of the last 13 on the bright blue courts in central Melbourne, Reuters reported.
Both have six titles each, and are seeking to break a three-way tie for the most victories with Australia’s Roy Emerson.
While Federer has won the tournament for the last two years, Djokovic’s history in Australia and rediscovery of his form last year means the world number one will be the man to beat.
The 31-year-old went into a bewildering slump in mid-2016 that only ended when he won Wimbledon last year before he went on to claim his third US Open crown and move to 14 Grand Slam titles, three behind Rafa Nadal.
The Spanish world number two, however, is battling another leg injury that forced him out of the Brisbane International last week and it is apparent that hard courts are putting undue stress on the 32-year-old’s body.
He retired in the quarterfinals against Marin Cilic last year in Melbourne and suffered yet another knee injury that forced him out of the US Open semifinals before he had ankle surgery in November.
Federer, however, continues to defy the odds at 37 and prepared for his title defense with some convincing performances in the Hopman Cup in Perth last week.
The 20-times Grand Slam winner’s victories over Greece’s world number 15 Stefanos Tsitsipas and world number four Alexander Zverev prompted the German to playfully quip that he was tired of Federer winning everything.
“I mean, you’re 30-whatever. Why? Just why?,” Zverev asked jokingly of Federer at the Hopman Cup trophy presentation.
The 21-year-old Zverev appears the most likely of the younger generation hoping to end the world’s top three’s domination of Grand Slams, having beaten Federer and Djokovic at the ATP Tour Finals in London last November.
While others in ‘Generation Next’ like Austria’s Dominic Thiem and the 22-year-old Russians Karen Khachanov and Daniil Medvedev could cause upsets, it is debatable whether they can win seven matches over 14 days.
Two of the older generation who have shown they do have that ability — Britain’s Andy Murray and Switzerland’s Stan Wawrinka — could be dangerous floaters in the draw.
Murray, a five-time finalist at Melbourne Park, spent most of last year recuperating from hip surgery and looked rusty last week in Brisbane but declared himself pain free.
Wawrinka, the 2014 champion, is also coming back from knee surgery and a back injury in the second half of 2018, but typically flies under the radar through Grand Slams.
Williams chasing 24
The women’s draw looks more open even with Serena Williams, the most dominant force in the sport, back and chasing a 24th Grand Slam singles title to tie Margaret Court’s all-time record.
The American was eight weeks pregnant when she won her 23rd title at Melbourne Park in 2017 and returned to action last year where she reached finals at Wimbledon and the US Open.
Williams enters the year’s first Grand Slam ranked 16th but she still remains the favorite in Melbourne even if she lost to Naomi Osaka in the Flushing Meadows final.
World number one Simona Halep, with a massive burden off her shoulders, will hope to go one better this year having lost the 2018 final to Caroline Wozniacki.
The Romanian broke her major duck at the French Open in June last year and finished the season at number one for the second consecutive year.
A second Australian Open title will be a perfect birthday gift for world number two Angelique Kerber, who turns 31 in the first week of the tournament.
Kerber beat Wiliams in the Wimbledon final to become the first German woman to win the grass court title since Steffi Graf in 1996.
She has looked sharp at the Hopman Cup and maintained her 100 percent singles record even though Germany lost to Federer’s Switzerland in the final.
Also in the mix is the popular Osaka, who stunned Williams in New York.
The 21-year-old Japanese, however, had an inconsistent buildup to the year’s first Grand Slam.
Osaka suffered a straight set loss to Lesia Tsurenko in the semifinal of the Brisbane International and withdrew from the Sydney International in frustration.