EU officials have insisted that the deal is not open for renegotiation. But May wrote in the Sunday Telegraph that she would be "battling for Britain and Northern Ireland" in her efforts to get rid of the agreement's unpopular backstop provision, Reuters reported.
"If we stand together and speak with one voice, I believe we can find the right way forward," she said.
The backstop is intended to ensure there is no return to a hard border with Ireland, but Brexit supporters fear it will keep Britain tied to the EU's customs rules.
MPs voted last week to send May back to Brussels to renegotiate the clause, suggesting her deal would then be able to pass after it was roundly rejected in parliament last month.
"I am now confident there is a route that can secure a majority in the House of Commons for leaving the EU with a deal," she wrote.
"When I return to Brussels I will be battling for Britain and Northern Ireland, I will be armed with a fresh mandate, new ideas and a renewed determination to agree a pragmatic solution".
The EU insists that the deal "remains the best and only way to ensure an orderly withdrawal," but with the clock running down until the March 29 exit date the risks of a no-deal Brexit for both Britain and the bloc are coming into sharp focus.
May said opposition leader Jeremy Corbyn "also believes the potential indefinite nature of the backstop is an issue", and that the EU has "already accepted the principle of 'alternative arrangements' superseding the backstop should it ever be required."
The backstop would kick in if Britain and the EU have not agreed a trade deal on their future relationship after a time-limited transition period of up to two years.
The prime minister rejected accusations that plans to reopen the backstop talks risked upsetting the Irish peace process.
"Nor do I have time for those who believe the verdict passed by the British people in 2016 should be overturned before it is even implemented," she added, referring to the rump of MPs calling for a second referendum.
"I'm determined to deliver Brexit, and determined to deliver on time â- on March 29, 2019," she wrote.
May has promised MPs that she will bring any revised deal back to be voted on by MPs on February 13.
Meanwhile, British Trade Minister Liam Fox said in an interview aired on Sunday that it would be irresponsible for the EU to refuse to reopen negotiations over Britain's exit deal,.
May is seeking changes to the Withdrawal Agreement she agreed with Brussels last year in order to win the support of Parliament. The EU has said the deal cannot be renegotiated.
"Are they really saying that they would rather not negotiate and end up in a 'no-deal' position?" Fox told Sky News in a pre-recorded interview. "It is in all our interests to get to that agreement and for the EU to say we are not going to even discuss it seems to me to be quite irresponsible."
Fox, who has previously spoken out strongly against delaying the exit date, said extending the negotiations without a deal in place would not solve anything, but it was "a very different argument" if Britain just needed more time to get the necessary legislation in place for a smooth exit.
He is the second senior minister to suggest such a delay may be needed, after Foreign Secretary Jeremy Hunt said on Thursday Britain may need time to get legislation through.
"There is a big difference between if we had an agreement and we need some time to get the legalities done, that is one thing," Fox said. "I think to extend simply because we hadn’t reached an agreement would not provide any impetus for that agreement to be reached."
Fox said Britain would "be able to deal" with leaving the bloc without an agreement but it would not be in the country's interests.