The trio were also absent from United's 3-2 win over Southampton on Saturday, with youngsters Angel Gomes and Tahith Chong named on the bench for that game, goal.com reported.
And both youngsters were also in the traveling party heading to Paris on Tuesday, while there was also a place for 17-year-old striker Mason Greenwood, and 17-year-old midfielder James Garner.
Paul Pogba, meanwhile, is absent after his red card in the first leg, which PSG won 2-0 courtesy of goals from Presnel Kimpembe and Kylian Mbappe.
The French World Cup winner was shown a second yellow card for a mistimed challenge on Dani Alves in the closing stages of the game at Old Trafford to add to Ole Gunnar Solskjaer's selection issues.
Spanish midfielder Juan Mata is another who hasn't traveled to Paris as he continues to nurse a hamstring injury that he suffered in the 0-0 draw with Liverpool.
United is almost back to its full complement of defensive players, however, with the likes of Victor Lindelof, Eric Bailly, Marcos Rojo and Chris Smalling all included.
Matteo Darmian and Phil Jones both haven't traveled, though, with Under-23s fullback Brandon Williams another young player who has been given the opportunity to join the 20-man squad.
United will have its work cut out to pull off a comeback against the Ligue 1 champion, although Solskjaer is adamant that his side does still have a chance of going through.
He told the club's official website, "We can't write games off, we've been fantastic away from home. We're not going to go out without giving a fight.
"We're going to go out there and enjoy the game. We know it's a difficult place to come and they played really well at Old Trafford, so it's a great challenge for our players to go out there and show what they can do."