“I don’t care about the stadium,” the Belgium international told reporters ahead of City’s first visit to the new 62,062-seater venue on Tuesday.
“I care about the team we play. Everybody talks about the stadium like it’s something special. Everybody has a stadium, everybody has supporters.
“They’ll be up for it, they’ll probably be a little bit more excited, but in the end it’s a stadium with supporters. I don’t think there will be any difference.”
City is second in the Premier League, two points behind Liverpool but having played a game less, and reached the final of the FA Cup after beating Brighton and Hove Albion 1-0 on Saturday.
Having already won the League Cup this season, City is still on track for a quadruple but De Bruyne said there is “no point thinking about it”.
“You know how heavy the schedule is? I think people underestimate how the fixtures come that quickly.
“We don’t even have time to have a rest ourselves so how can we think about what’s going to happen in four weeks?”