Watford striker Troy Deeney – who blocked replies to his Instagram account earlier this month after receiving abuse – summed up the anger he and fellow footballers feel, saying, "Enough is enough," AFP reported.
The campaign, which is being coordinated by England's Professional Footballers' Association, urges players to stay off all social media from 9:00 a.m. (0800 GMT) Friday.
The universal message across the footballers' Twitter accounts used the hashtag #Enough with the message "MAKE A STAND AGAINST RACISM – A campaign by the PFA".
The PFA said the boycott was the "first step in a longer campaign to tackle racism in football".
The boycott is not just aimed at those who use the platforms to air their racist views but also at the social media companies themselves and football authorities.
There have been growing concerns over how football should tackle racism following a number of incidents of abuse both at grounds and on social media.
England's black players faced repeated racist chants during their Euro 2020 qualifier in Montenegro last month.
One of those targeted, fullback Danny Rose, said afterward he could not wait to turn his "back on football".
Some like Liverpool manager Jurgen Klopp – whose star player Mohamed Salah was the target of Islamophobic abuse by Chelsea fans last week – has said he would have no hesitation in taking his players off the pitch.
"If it's the whole stand, then I would do it 100 percent," Klopp said after the Montenegro incidents.
"But that's too much power for one or two idiots or three or four idiots. But if the whole stand would do it then it is completely different."
'Protecting mental health'
For the moment though the likes of prolific tweeter Raheem Sterling – who has been subject to abuse from Chelsea fans and then in Montenegro this season – and Harry Kane will have to resist the urge to tweet or post on Instagram.
Liverpool's England defender Trent Alexander-Arnold was among those who posted the PFA message on his Instagram account on Friday morning.
"We are making a stand against racist abuse," said a message on his account.
"We recognize that our platforms come with responsibility, and so we are using our voice to stand against racist abuse.
"Together, we are calling on social media platforms and footballing bodies to do more!"
Manchester United's central defender Chris Smalling – whose teammate Ashley Young was the victim of racist abuse after a mistake during the Champions League defeat to Barcelona on Tuesday – echoed these sentiments, warning harmful and hate-filled posts can have a debilitating impact on those targeted.
"Throughout my career I have developed a thick skin against verbal abuse, justifying it as just 'part of the game' but the time has come for Twitter, Instagram and Facebook to consider regulating their channels, taking responsibility for protecting the mental health of users regardless of age, race, sex or income," Smalling said.
Twitter has defended itself, saying it is "suspending three times more abusive accounts within 24 hours after receiving a report than this time last year".
"We'll continue building on this work to prioritize the safety of our users," Twitter said.
Facebook too took action earlier this week in banning the likes of far right bodies such as Britain First and the British National Party whose members would be natural purveyors of racist abuse.