0755 GMT October 19, 2019
The data, reported at the ESMO World Congress on Gastrointestinal Cancer 2019, suggest that the three-drug combination, encorafenib, binimetinib and cetuximab, should replace chemotherapy for the one in seven patients with metastatic colorectal cancer who have a BRAF mutation, according to medicalxpress.com.
"These are very exciting results because we've been trying to target BRAF-mutant colorectal cancer for many years. It's encouraging to see such a significant improvement in overall survival and response in patients with such aggressive tumor biology. Hopefully, this will soon lead to increased access to this treatment for patients where there is currently such a large unmet need," said study author Dr. Scott Kopetz, from the UT MD Anderson Cancer Center, Houston, USA.
Kopetz explained that the three-drug combination builds on growing understanding of the activation of cancer genes such as BRAF and the effects of targeted therapies. "Colorectal cancer does not respond to BRAF therapy alone because tumor cells adapt through other mechanisms after initial treatment. With this triple targeted therapy, we are using a very scientifically logical combination to inhibit BRAF and these other mechanisms," he pointed out.
Commenting on the relevance of the new data, Prof. Andres Cervantes from the Biomedical Research Institute INCLIVA, University of Valencia, Spain, stressed that it will be important for all patients with colorectal cancer to be tested for BRAF mutations in the light of the BEACON CRC findings. "We now have a specific treatment that can change the natural course of the disease in patients with BRAF mutations and is better than previous therapy, so it is essential that patients are routinely tested."
He also highlighted the chemotherapy-free nature of the targeted combination used in the study. "In many other types of cancer, and particularly in colorectal cancer, it is common for biological targeted therapies to be used in combination with chemotherapy. The fact that we can give this targeted combination without the need for chemotherapy is very good news for patients, not least because of the side effects that they typically experience with chemotherapy," he added.
"At present, targeted therapy should probably be limited to the patient group treated in the BEACON CRC trial who had progressed after one or two previous lines of chemotherapy. However, it is important that we investigate its use in other settings where more patients with BRAF mutations may also benefit, including those with less advanced metastatic disease and possibly in the adjuvant setting after primary surgery with curative intent," concluded Cervantes.