Juventus visits fifth-placed Atalanta before hosting Atletico Madrid in the Champions League next week, AFP reported.
Maurizio Sarri's side is just one point ahead of Antonio Conte's Inter Milan after 12 matches, with Lazio and Cagliari eight points adrift of the leaderin joint third.
Atalanta has gone three league games without a win and will be eager to get back into the Champions League berths, as it sits two points off fourth place, before next week's trip to Shakhtar Donetsk.
Atalanta's fortunes have slipped following the thigh injury suffered to Colombian star Duvan Zapata, who scored six goals in six Serie A matches before being sidelined for the last five league games.
As Atalanta sweats on Zapata's return, Juventus will be without fullback Alex Sandro, who picked up a thigh problem playing for Brazil, with Blaise Matuidi recovering from a rib injury.
Ronaldo had said he was not be at his best physical form, with Sarri saying the Portuguese star has a "little knee problem."
But the 34-year-old wants to make amends after storming off when he was substituted in Juventus's last game against AC Milan.
"In the last three weeks, I have played at a slightly reduced capacity," Ronaldo conceded after his goal spree for Portugal.
"I don't like to be replaced, no one does," added Ronaldo.
"I tried to help Juve even when injured."
Fullback Danilo, who scored his first goal for Brazil during the international break, warned, "The games after the international break are never easy, let alone against Atalanta, a team who are doing well.
"We can't make mistakes or underestimate them."
Inter will be looking to make it a perfect seven league games on the road this season as it travels to Torino, before its European trip to Slavia Prague.
Conte's side faces a tough task against the Andrea Belotti-powered Torino, which ended its six-match winless run against Brescia last time out, and is in 11th position.
Serie A runner-up Napoli is in crisis, having slipped to seventh, and desperately needs a result at 14th-placed AC Milan, which is itself floundering.
Cagliari and Lazio will look to continue their strong form at lowly Lecce and Sassuolo respectively.