Antetokounmpo had 27 points and 11 rebounds before exiting the game with 8:56 to play and his Milwaukee Bucks ahead by 36, The Associated Press reported.
The Bucks went on to win 119-91 and capture their 14th straight victory.
The reigning MVP made 11 of 20 shots and recorded his 21st double-double of the season.
“It was Giannis’ birthday and we searched all over the city to find a gift and we couldn’t find one, so we gave him this one,” Clippers coach Doc Rivers said.
“That’s all I can come up with because we were awful.”
The Bucks led by as many as 41 and extended their longest winning streak since winning 16 consecutive games over two seasons in 1973.
Khris Middleton added 17 points and Pat Connaughton and Ersan İlyasova each scored 13 off the bench for Milwaukee.
“We were just still stagnant at the beginning of the fourth,” Clippers’ Kawhi Leonard said. “We weren’t really running anything, not executing. Coming down, taking shots early with no passes. So, I mean, I understand why he pulled us. Plus the lead was up high and we really didn’t have no type of momentum.”
Leonard had 17 points and Paul George added 13 for the Clippers.
Friday night was the first time Leonard and Antetokounmpo faced each other since the Eastern Conference finals in May, when Leonard’s Toronto Raptors beat Antetokounmpo and the Bucks in six games en route to winning the NBA championship.
Leonard said the biggest difference between Antetokounmpo then and now is he’s shooting the ball with more confidence.
“Obviously, yes, I’m a little more confident with my jump shot,” he said. “I believe in myself more. I think my teammates believe in me even more this year. But I’m just aggressive. Since the year started, I’ve been on a mission to help my team win every night and I think I’ve stayed on that path.”