Marc Gasol added 20 points to become one of seven players in double figures for the Raptors, who have won seven straight games over the Wizards, AFP reported.
The Raptors tied their franchise points total of 140 points which they earned in a double overtime two-point victory over the Wizards in January 2019. It is the most points they have ever scored in regulation time.
Toronto has been struggling to hold big leads of late, but it hopes to have finally reversed that trend with Friday's season-high scoring total.
The Raptors led 38-26 at the end of the first quarter and took a 24-point lead into the fourth quarter. They increased it to 30 points with 4:36 remaining and cruised from there to improve to 27-14 on the season.
Terence Davis scored 23 points, OG Anunoby added 18 points and Serge Ibaka had 15 points and eight rebounds. Pascal Siakam had 12 points, and Kyle Lowry contributed 11 points and eight assists.
Troy Brown had 22 points for the Wizards, who have lost three straight. Isaac Bonga added 17 points and 10 rebounds.
Bradley Beal had 14 points, Ish Smith and Davis Bertans each had 12 and Anzejs Pasecniks 11 in the loss.
Toronto shot 57.1 percent from the field and are now 20-4 against Washington dating back to the 2013-14 NBA season.
Elsewhere, Malcolm Brogdon drained a clutch basket with 18 seconds remaining as the Indiana Pacers spoiled the return of Karl-Anthony Towns with a tightly-contested 116-114 victory over the Minnesota Timberwolves.
Brogdon hit a tiebreaking 15 footer, and T.J. Warren scored 28 points for the Pacers in front of a crowd of 17,900 at Bankers Life Fieldhouse.
Two-time all-star center Towns finished with 27 points after missing 15 games with a knee injury.
"I am just so happy basketball is here for me, because it was some great therapy for me today," he said.