0855 GMT December 09, 2019
Now a team of researchers, led by a biomedical scientist at the University of California, reports that it has identified just such a drug in the lab: indazole chloride (Ind-Cl), according to phys.org.
"This drug, which we administered on transgenic mice, can potentially halt the symptoms and reverse ongoing motor deficit due to MS," said Seema K. Tiwari-Woodruff, an associate professor in the UC Riverside School of Medicine whose lab led the study. "Our study shows that Ind-Cl can remyelinate axons which have gotten injured not just in MS but also traumatic brain injury and spinal cord injury."
MS an autoimmune disease of the brain and spinal cord, affects about 2.3 million people worldwide (400,000 in the US). Affecting more women than men, it can be seen at any age, although it is most commonly diagnosed between the ages of 20 and 40.
An unpredictable disease that disrupts the flow of information within the brain and between the brain and the body, MS is triggered when the immune system attacks the myelin sheath, the protective covering around the axons of nerve fibers. The "demyelination" causes a disruption of nerve impulses. As the protective sheath — best imagined as the insulating material around an electrical wire — wears off, the nerve signals slow down or stop, and the patient's vision, sensation and use of limbs get impaired. Permanent paralysis can result when the nerve fibers are completely damaged by the disease.