News ID: 56687
Published: 1212 GMT December 03, 2014

Chemical reduces effects of MS

Chemical reduces effects of MS

A drug that could minimize the degeneration of axons, thus reducing the rate and degree of multiple sclerosis (MS) progression, would be immensely helpful. Better still would be if this drug could stimulate "remyelination," the re-sheathing of the axons, restoring fast and uninterrupted flow of nerve impulses.


Now a team of researchers, led by a biomedical scientist at the University of California, reports that it has identified just such a drug in the lab: indazole chloride (Ind-Cl), according to

"This drug, which we administered on transgenic mice, can potentially halt the symptoms and reverse ongoing motor deficit due to MS," said Seema K. Tiwari-Woodruff, an associate professor in the UC Riverside School of Medicine whose lab led the study. "Our study shows that Ind-Cl can remyelinate axons which have gotten injured not just in MS but also traumatic brain injury and spinal cord injury."

MS an autoimmune disease of the brain and spinal cord, affects about 2.3 million people worldwide (400,000 in the US). Affecting more women than men, it can be seen at any age, although it is most commonly diagnosed between the ages of 20 and 40.

An unpredictable disease that disrupts the flow of information within the brain and between the brain and the body, MS is triggered when the immune system attacks the myelin sheath, the protective covering around the axons of nerve fibers. The "demyelination"  causes a disruption of nerve impulses. As the protective sheath — best imagined as the insulating material around an electrical wire — wears off, the nerve signals slow down or stop, and the patient's vision, sensation and use of limbs get impaired. Permanent paralysis can result when the nerve fibers are completely damaged by the disease.

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