A drug commonly used to manage symptoms of Alzheimer disease and other dementias — donepezil — is associated with a two-fold higher risk of hospital admission for rhabdomyolysis, a painful condition of muscle breakdown, compared with several other cholinesterase inhibitors, found a study in CMAJ (Canadian Medical Association Journal).
For decades, researchers have sought a blood test for beta amyloid, the protein that is a hallmark of Alzheimer’s disease. Several groups and companies have made progress. Scientists at Washington University in St. Louis reported that they had devised the most sensitive blood test yet.
Dementia has four main types — vascular dementia, Alzheimer’s disease, frontotemporal dementia and Lewy body dementia. In the UK, figures have shown around 60 percent of diagnoses of dementia are Alzheimer’s disease.
New research shows that a blood test for Alzheimer's disease accurately detected levels of beta-amyloid protein in all stages of the condition, approaching "a level of accuracy that is usable in routine clinical care around the world."
Neuroscientist Barbara Bendlin studies the brain as Alzheimer’s disease develops. When she goes home, she tries to leave her work in the lab. But one recent research project has crossed into her personal life: She now takes sleep much more seriously.