Using a targeted gene epigenome editing approach in the developing mouse brain, Johns Hopkins Medicine researchers reversed one gene mutation that leads to the genetic disorder WAGR syndrome, which causes intellectual disability and obesity in people. This specific editing was unique in that it changed the epigenome — how the genes are regulated — without changing the actual genetic code of the gene being regulated.
Scientists are experimenting with all kinds of ideas to extend lifespan and give us a few extra years of existence, and now a mouse study has produced some intriguing results: A longer life thanks to hyper-long telomeres.
Directly activating a gene important to exciting our excitatory neurons and associated with major depression may help turn around classic symptoms like social isolation and loss of interest, at least for males, scientists report.
Stanford University School of Medicine researchers have demonstrated that gene therapy can be effective without causing a dangerous side effect common to all gene therapy: An autoimmune reaction to the normal protein, which the patient's immune system is encountering for the first time.
A study published in the journal Cell Death and Disease showed that the mice developed with wrinkled skin and visible hair loss could be restored by turning off a gene, lending a clue for potential therapy against aging.