A new study by researchers at The Picower Institute for Learning and Memory at MIT finds that the protein CPG2 is significantly less abundant in the brains of people with bipolar disorder (BD) and shows how specific mutations in the SYNE1 gene that encodes the protein undermine its expression and its function in neurons.
Two to three million years ago, the functional loss of a single gene triggered a series of significant changes in what would eventually become the modern human species, altering everything from fertility rates to increasing cancer risk from eating red meat.
A study published in the journal Cell Death and Disease showed that the mice developed with wrinkled skin and visible hair loss could be restored by turning off a gene, lending a clue for potential therapy against aging.
Researchers from University of Texas Southwestern Medical Center in the US showed that turning on a gene inside cells called astrocytes results in a smaller scar and potentially more effective recovery from injury.
Early evidence suggested that gene therapy developed at St. Jude Children's Research Hospital will lead to broad protection for infants with the devastating immune disorder X-linked severe combined immunodeficiency disorder.